Molecular Biology 2010

Week 0: Spectroscopy

This year I volunteered to give an introduction to spectroscopy during "week 0". I hope the student enjoyed it as much as I did. Here is the handout:

spectroscopy.pdf size: 2.7MB; md5sum: 3471c2cefb2739ff8619b739bbfeb59d

Macromolecular Crystallography

These are the handouts for the actual lectures and tutorials:

Day 1 (Oct 26^th): Slides size: 4.9MB; md5sum: 20dba0b6119251a8ca9fb94f3e0673bb
Keywords: X-rays, Crystals, Spacegroups and Symmetry, Phasing (MR, MIR, S/MAD)

Day 2 (Oct 29^th): Tutorial Study questions size: 1.1MB; md5sum: 20dba0b6119251a8ca9fb94f3e0673bb

Day 3 (Nov 1^st): Slides size: 7.4MB; md5sum: 040cf65f3fe110198918b0f2424a9b43
Keywords: Refinement and Model Building, Validation

Day 4 (Nov 2^nd): Discussion of the following articles:

• Pornillos, O. et al., X-ray Structure of the EmrE Multidrug Transporter in Complex with a Substrate, Science (2005), Vol. 310, pp. 1950-1953
• Rydberg, E. H. et al., Structural Basis for Resistance of the Genotype 2b Hepatitis C Virus NS5B Polymerase to Site A Non-Nucleoside Inhibitors, JMB (2009), Vo. 390, pp. 1048-1059
• Levdikov, V. M., et al., Structural Rearrangement Accompanying Ligand Binding in the GAF Domain of CodY from Bacillus subtilis

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Tim Grüne

Last modified: Mar 25, 2020 22:33