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Publications


Mariann Gyöngyösi, Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Georg Goliasch, Ljubica Mandic, Jutta Bergler-Klein, Alfred Gugerell, Andras Jakab, Zsuzsanna Szankai, Levente Toth, Rita Garamvölgyi, Gerald Maurer, Frederic Jaisser, Faiez Zannad, Thomas Thum, Sándor Bátkai, and Johannes Winkler
Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension
Journal of Translational Medicine 2017, 15, 202.

Mariann Gyöngyösi, Dominika Lukovic, Katrin Zlabinger, Ljubica Mandic, Johannes Winkler, and Alfred Gugerell
Cardiac Stem Cell-based Regenerative Therapy for the Ischemic Injured Heart - a Short Update 2017
Journal of Cardiovascular Emergencies 2017, 3, 81-83.

Michael Blaschke, Martin Zehl, Beatrix Hartl, Claudia Strauß, Johannes Winkler, Ernst Urban, Georg Krupitza, and Brigitte Kopp
Isolation of eudesmanes from Pluchea odorata and evaluation of their effects on cancer cell growth and tumor invasiveness in vitro
Phytochemistry 2017, 141, 37-47.

Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, David Lorant, Georg Goliasch, Johannes Winkler, Dietmar Pils, Katharina Auer, Hendrik Jan Ankersmit, Zoltán Giricz, Márta Sárközy, András Jakab, Rita Garamvölgyi, Maximilian Y. Emmert, Simon P. Hoerstrup, Derek J Hausenloy, Péter Ferdinandy, Gerald Maurer, and Mariann Gyöngyösi
Intrinsic remote conditioning of the myocardium as a comprehensive cardiac response to ischemia and reperfusion
Oncotarget 2017, 8, 6722767240.

Francisco Fernández-Avilés et al.; TACTICS writing group
Global position paper on cardiovascular regenerative medicine: Scientific statement of the transnational alliance for regenerative therapies in cardiovascular syndromes (TACTICS) international group for the comprehensive cardiovascular application of regenerative medicinal products
European Heart Journal 2017, 38, 2532-2546.

Juozas Baltusnikas, Andrej Fokin, Johannes Winkler, and Julius Liobikas
Long-term regulation of gene expression in muscle cells by systemically delivered siRNA
Journal of Controlled Release 2017, 256, 101-113.

Antonia Geyer, Cornelia Lorenzer, Sebastian Gehrig, Manuela Simlinger, Johannes Winkler, Haider Sami, and Manfred Ogris
Fluorescence- and computed tomography for assessing the biodistribution of siRNA after intratracheal application in mice
International Journal of Pharmaceutics 2017, 525, 359-366.

Volker Baumann, Cornelia Lorenzer, Michael Thell, Anna-Maria Winkler, and Johannes Winkler
RNAi-mediated knockdown of protein expression
Methods in Molecular Biology 2017, 1654, 351-360.

Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, Abelina Zimba, David Lorant, Georg Goliasch, Johannes Winkler, Dietmar Pils, Katharina Auer, Hendrik Jan Ankersmit, Zoltán Giricz, Tamas Baranyai, Márta Sárközy, András Jakab, Rita Garamvölgyi, Maximilian Y. Emmert, Simon P. Hoerstrup, Derek J Hausenloy, Péter Ferdinandy, Gerald Maurer, and Mariann Gyöngyösi
Sequential activation of different pathway networks in ischemia-affected and non-affected myocardium, inducing intrinsic remote conditioning to prevent left ventricular remodeling
Scientific Reports 2017, 7, 43958.

Dominika Lukovic, Katrin Zlabinger, Alfred Gugerell, Andreas Spannbauer, Noemi Pavo, Ljubica Mandic, Denise Traxler-Weidenauer, Stefan Kastl, Christoph Kaun, Aniko Posa, Inna Sabdyusheva-Litschauer, Johannes Winkler, and Mariann Gyöngyösi,
Inhibition of CD34+ cell migration by matrix metalloproteinase-2 during acute myocardial ischemia, counteracted by ischemic preconditioning
F1000Research 2017, 5, 2739.

Mariann Gyöngyösi, Johannes Winkler, Isbaal Ramos, Quoc-Tuan Do, Hüseyin Firat, Kenneth McDonald, Arantxa González, Thomas Thum, Javier Díez, Frédéric Jaisser, Anne Pizard, and Faiez Zannad Myocardial fibrosis: biomedical research from bench to bedside
European Journal of Heart Failure 2017, 19, 177-191.

Ljubica Mandic, Denise Traxler, Alfred Gugerell, Katrin Zlabinger, Dominika Lukovic, Noemi Pavo, Georg Goliasch, Andreas Spannbauer, Johannes Winkler, and Mariann Gyöngyösi
Molecular Imaging of Angiogenesis in Cardiac Regeneration
Current Cardiovascular Imaging Reports 2016, 9, 1-11.

Mehrdad Dirin, Ernst Urban, Christian R. Noe, and Johannes Winkler
Fragment-based Solid-Phase Assembly of Oligonucleotide Conjugates with Peptide and Polyethylene Glycol Ligands
European Journal of Medicinal Chemistry 2016, 121, 132-142.

Katharina Waldbauer, Günter Seiringer, Dieu Linh Nguyen, Johannes Winkler, Michael Blaschke, Ruxandra McKinnon, Ernst Urban, Angela Ladurner, Verena M. Dirsch, Martin Zehl, and Brigitte Kopp
Triterpenoic acids from apple pomace enhance the activity of the endothelial nitric oxide synthase (eNOS)
Journal of Agricultural and Food Chemistry 2016, 64, 185–194.

Mehrdad Dirin, Ernst Urban, Bodo Lachmann, Christian R. Noe, and Johannes Winkler
Concise post-synthetic preparation of oligonucleotide oligopeptide conjugates through facile disulfide bond formation
Future Medicinal Chemistry 2015, 7, 1657-1673.

Johannes Winkler
Therapeutic oligonucleotides with polyethylene glycol modifications
Future Medicinal Chemistry 2015, 7, 1721-1731.

Cornelia Lorenzer, Mehrdad Dirin, Anna-Maria Winkler, Volker Baumann, and Johannes Winkler
Going beyond the liver: Progress and challenges of targeted delivery of siRNA therapeutics
Journal of Controlled Release 2015, 203, 1-15.

Nasrin Shokrzadeh, Anna-Maria Winkler, Mehrdad Dirin, and Johannes Winkler
Oligonucleotides conjugated with short chemically defined polyethylene glycol chains are efficient antisense agents
Bioorganic & Medicinal Chemistry Letters 2014, 24, 5758-5761.

Volker Baumann, and Johannes Winkler
miRNA-based therapies: Strategies and delivery platforms for oligonucleotide and non-oligonucleotide agents
Future Medicinal Chemistry 2014, 6, 1967-1984.

Zuzana Gažiová, Volker Baumann, Anna-Maria Winkler, and Johannes Winkler
Chemically defined polyethylene glycol siRNA conjugates with enhanced gene silencing effect
Bioorganic & Medicinal Chemistry 2014, 22, 2320-2326.

Kerstin Kainz, Martin Zehl, Johanna Bleier, Barbara Merkinger, Teresa Pemmer, Natalie Schmidt, Johannes Winkler, Hanspeter Kählig, and Liselotte Krenn
Secondary metabolites of the tree fern Metaxya rostrata C. Presl
Records of Natural Products 2014, 8, 348-353.

Barbara A. Theiler, Silvia Revoltella, Martin Zehl, Christina Dangl, Lugardo O. Espinoza Caisa, Jürgen König, Johannes Winkler, Ernst Urban, and Sabine Glasl
Secundarellone A, B, and C from Justicia secunda Vahl
Phytochemistry Letters 2014, 10, cxxix–cxxxii.

Johannes Winkler
Oligonucleotide Conjugates for Therapeutic Applications
Therapeutic Delivery 2013, 4, 791-809.

Mehrdad Dirin, and Johannes Winkler
Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides
Expert Opinion on Biological Therapeutics 2013, 6, 875–888.

Martina Stessl, Christian R. Noe and Johannes Winkler
Off-target effects and safety aspects of phosphorothioate oligonucleotides
From Nucleic Acid Sequences to Molecular Medicine - RNA Technologies 2012, 67-93.

Evelien Rozema, Ruxandra Popescu, Harald Sonderegger, Christian W. Huck, Johannes Winkler, Georg Krupitza, Ernst Urban and Brigitte Kopp
Characterization of Glucocerebrosides and the Active Metabolite 4,8-Sphingadienine from Arisaema amurense and Pinellia ternata by NMR and CD Spectroscopy and ESI-MS/CID-MS
J. Agric. Food Chem. 2012, 60, 7204-7210.

Johannes Winkler
Nanomedicines based on recombinant fusion proteins for targeting therapeutic siRNA oligonucleotides
Ther. Deliv. 2011, 2, 891-905.

Winfried Neuhaus, Michael Freidl, Phillip Szkokan, Michael Berger, Michael Wirth, Johannes Winkler, Franz Gabor, Christian Pifl and Christian R. Noe,
Effects of NMDA receptor modulators on a blood–brain barrier in vitromodel
Brain Res. 2011, 1394, 49-61.

Johannes Winkler, Martina Stessl, Jennifer Amartey and Christian R. Noe
Off-target Effects Related to the Phosphorothioate Modification of Nucleic Acids
ChemMedChem 2010, 5, 1344-1352.

Johannes Winkler, Benedikt Giessrigl, Clemens Novak, Ernst Urban and Christian R. Noe
2’-O-Lysylaminohexyladenosine-Modified Oligonucleotides
Monatsh. Chem. 2010, 141, 809-815.

Winfried Neuhaus, Martina Stessl, Elisabeth Strizsik, Barbara Bennani-Baiti, Michael Wirth, Stefan Toegel, Maaya Modha, Johannes Winkler, Franz Gabor, Helmut Viernstein and Christian R. Noe
Blood-Brain Barrier mimicking cell line PBMEC/C1-2 Possesses Functionally Active P-glycoprotein
Neurosci. Lett. 2010, 469, 224-228.

Johannes Winkler, Patricia Martin-Killias, Andreas Plückthun, and Uwe Zangemeister-Wittke
EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with Designed Ankyrin Repeat Proteins
Mol. Cancer Ther. 2009, 8, 2674-2683.

Martina Stessl, Martina Marchetti-Deschmann, Johannes Winkler, Bodo Lachmann, Günter Allmaier, and Christian R. Noe
A proteomic study reveals unspecific apoptosis induction and reduction of glycolytic enzymes by the phosphorothioate antisense oligonucleotide oblimersen in human melanoma cells
J. Proteomics 2009, 72, 1019-1030.

Johannes Winkler, Mónica Díaz-Gavilán, Karmin Saadat, Ernst Urban, and Christian R. Noe
Oligonucleotide Polyamine Conjugates: Influence of Length and Position of 2’-Attached Polyamines on Duplex Stability and Antisense Effect
Eur. J. Med. Chem. 2009, 44, 670-677.

Johannes Winkler, Matthias Gilbert, Aneta Kocourková, Martina Stessl, and Christian R. Noe
2’-O-Lysylaminohexyl Oligonucleotides: Modifications for Antisense and siRNA
ChemMedChem 2008, 3, 102-110.

Johannes Winkler, and Christian R. Noe
Oligonucleotide Charge Reversal: 2'-O-Lysylaminohexyl Modified Oligonucleotides
Nucleosides Nucleotides Nucl. Acids 2007, 26, 939-942.

Christian R. Noe, Johannes Winkler, Ernst Urban, Matthias Gilbert, Georg Haberhauer, and Helmut Brunar
Zwitterionic Oligonucleotides: A Study on Binding Properties of 2'-O-Aminohexyl Modifications
Nucleosides Nucleotides Nucl. Acids, 2005 24, 1167-1185.

Johannes Winkler, Ernst Urban, and Christian R. Noe
Oligonucleotides Conjugated to Short Lysine Chains
Bioconjugate Chem. 2005, 16, 1038-1044.

Johannes Winkler, Ernst Urban, Doris Losert, Volker Wacheck, Hubert Pehamberger, and Christian R. Noe
A Novel Concept for Ligand Attachment to Oligonucleotides via a 2'-Succinyl Linker
Nucl. Acids Res. 2004, 32, 710-718.

Johannes Winkler, Ernst Urban, and Christian R. Noe
-Methyl-2-amino-2,3-didesoxyribofuranoside, a Novel Building Block for Backbone Modified Antisense Oligonucleotides
Monatsh. Chem. 2004, 135, 109-116.



Grants and Awards


PRIZE (Austria Wirtschaftsservice)
Oligonucleotide-Conjugates for Improving the Pharmacokinetic Properties of Antisense and siRNA
2014-2016

Innovative Medicine Initiative (IMI) Joint Programme
COMPACT – Collaboration on the Optimization of Macromolecular Pharmaceutical Access to Cellular Targets
2012-2017

Johanna Mahlke-Obermann Stiftung
Synthetically Lethal Therapeutic Oligonucleotides
2011-2015

Internationales DACH Projekt (FWF und SNF)
Tumor-targeting of therapeutic oligonucleotides with DARPins
2010-2014

Erwin Schrödinger Post-Doc Stipendium
Antisense and siRNA Drug Delivery Using Antibody Fragments
Universität Bern, Switzerland, 2007-2008

Universidad de Granada, Spain, 1999 Erasmus Stipendum (Diplomarbeit)

INiTS Preis, 2005

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