cardiovascular progenitor cells / cardiac stem cells / embryonic stem cells / cardiomyogenesis / Desmin / Nkx2.5 /SPARC / ...

Molecular mechanisms guiding cardiomyogenesis

Homepage of Georg Weitzer

Principal investigator at the Center for Medical Biochemistry of the Medical University of Vienna

located at the Max F. Perutz Laboratories, Vienna Biocenter.

Mission statement

We pursue to unravel some molecular aspects of early mammalian cardiomyogenesis.We are interested in signaling and genetic regulation of commitment and differentiation of cardiac stem cells and the transcriptional balancing of self-renewal and differentiation in adult cardiac stem cells. (11.5.2018)


Recent publications:

Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene.
Fuchs, C., Gawlas, G., Heher, P., Nikouli, S., Paar, H., Ivankovic, M., Schultheis, M., Klammer, J., Gottschamel, T., Capetanaki, Y., and Weitzer, G.
(2016) Biology Open,Jan 19;5(2):140-53. Link to Biology Open
Small molecule Cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineagecommitted progenitor cells.Agnes K. Mike, Xaver Koenig, Moumita Koley, Philipp Heher, Gerald Wahla, Lena Rubia, Michael Schnürch, Marko D. Mihovilovic, Georg Weitzer, Karlheinz Hilber.(2014) Cellular Physiology and Biochemistry, 33(1), 205-221. DOI: 10.1159/000356663.
Reconsidering pluripotency tests: do we still need teratoma assays? Buta C, David R, Dressel R, Emgård M, Fuchs C, Gross U, Healy L, Hescheler J, Kolar R, Martin U, Mikkers H, Müller FJ, Schneider RK, Seiler AE, Spielmann H, Weitzer G.Stem Cell Res. 2013 Jul;11(1):552-562.DOI: 10.1016/j.scr.2013.03.001.
Embryonic Stem Cells Facilitate the Isolation of Persistent Clonal Cardiovascular Progenitor Cell Lines and Leukemia Inhibitor Factor Maintains Their Self-Renewal and Myocardial Differentiation Potential in vitro. Hoebaus, J., Heher, P., Gottschamel, T., Scheinast, M., Auner, H., Walder, D., Wiedner, M., Taubenschmid, J., Miksch, M., Sauer, T., Schultheis, M., Kuzmenkin, A., Seiser, C., Hescheler, J., Weitzer, G. Cells, tissues, organs. (2013);197(4):249-268 DOI: 10.1159/000345804
VUT-MK142 - A new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm to cardiomyocytes. Moumita Koley, Agnes K. Mike, Philipp Heher, Xaver Koenig, Michael Schön, Michael Schnürch, Karlheinz Hilber, Georg Weitzer, and Marko D. Mihovilovic. (2013) Medicinal Chemistry Communications. Med. Chem. Commun., 2013, 4, 1189-1195. DOI: 10.1039/C3MD00101F
Mechanisms of Cardiogenesis in Cardiovascular Progenitor Cells. Taubenschmid, J. and Weitzer, G.(2012) Int Rev Cell Mol Biol. 293, 195- 267.

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Last modifications 21.11.2019

Alter Zählerstand bis September 2018: 12419