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Biological
Barriers in Health and Disease
Welcome to the website of the group of
Dr. Neuhaus. We are working on the function
of biological barriers in health and
disease. The main focus is set on the
blood-brain barrier, the lung alveolar
epithelium and the kidney proximal tubulus.
In several diseases such as stroke,
traumatic brain injury or sepsis the
stabilization of biological barriers can
contribute to a less adverse outcome and
represent a promising therapeutic target.
SUMMARY OF NEWS of last year
(2022/2023):
Highlights are summarized here:
- Reviews/books:
Nanotechnological
approaches for improved para - and
transcellular drug delivery for brain
and retinal diseases (Nanoscale Horiz.,
IF 9.7)
- Topic 3Rs & NAMs:
The
rise of 3Rs centres and platforms in
Europe (ATLA, IF 2.7)
The
current status and work of 3Rs centres
and platforms in Europe (ATLA, IF 2.7)
Incorporation
of NAMs into regulatory nonclinical
pharmaceutical safety assessment (ALTEX,
IF 5.6)
Open
Letter: Selection of a new Executive
Director of the European Chemicals
Agency (ECHA) (ALTEX, IF 5.6)
- Topic blood-brain barrier:
CNS
pharmacokinetics of novel dopamine
transporter inhibitor CE-123 (Int. J.
Mol. Sci., IF 5.6)
Subcellular
trafficking and transcytosis efficacy of
different receptors for antibody
delivery across the BBB (FBCNS, IF 7.3)
Influence
of cells of the neurovascular unit in an
hiPSC- based late onset Alzheimer's
disease model (FBCNS,
IF 7.3)
A hydrogel BBB in vitro model based
on hiPSCs (PLoS One, IF 3.7)
Activation
of non-classical NMDARs by glycine
impairs function of brain
endothelial cells (Cell Mol. Life
Sci., IF 8.0)
- Topic biological
barriers:
Nanoparticle
toxicity in mucosa models to study the
uptake via the air pathway is dependent
on the cultivation modality and barrier
maturity (Int. J. Mol. Sci., IF 5.6)
A
primary cell based model of the human
small intestine reveals host
olfactomedin 4 induction in response to
Salmonella Typhimurium infection
(Gut microbes, IF 12.2)
A
human stem-cell derived brain-liver chip
for assessment of BBB drug permeation
(Cells, IF 6.0)
APPOINTMENT to PROFESSOR FOR 3Rs AND
NAMs (New approach methodologies),
October 2022, here some collected media
reports:
ORF online, 3.10.2022:
Privatuni
Krems: Erste Professur für Alternativen
zum Tierversuch - science.ORF.at
NÖN,
3.10.2022:
"Starker
neuer Impuls" - Erste Professur für
Alternativen zum Tierversuch an DPU
Krems - NÖN.at (noen.at)
Salzburger Nachrichten, 3.10.2022:
Erste
Professur für Alternativen zum
Tierversuch an DPU Krems | SN.at
Heute, 3.10.2022:
Statt
Tierversuchen – Privatuni sucht nun
Alternativen – Niederösterreich |
heute.at
Kurier, 5.10.2022:
Erste
Professur für Alternativen zum
Tierversuch an DPU Krems | kurier.at
Kronen Zeitung, 8.10.2022:
An
Kremser Privat-Uni - Alternativen zu
Tierversuchen werden nun erforscht |
krone.at
Salzburger Nachrichten, 22.11.2022:
Professor
sucht Alternativen zu Tierversuchen |
SN.at
SUMMARY OF NEWS of last years (2020-2022):
About 20 contributions have been
published, the highlights are summarized
here:
- Reviews/books
Review about Extracellular
vesicles as cancer biomarkers (Adv. Drug
Delivery Revs, IF 15.47)
Book chapter about Blood-brain
barrier in vitro models (Handb Exp
Pharmcol)
Book chapter about Guidelines
about transport studies across BBB models
(Handb Exp Pharmacol)
Book Physiology,
Pharmacology and Pathology of the
Blood-Brain Barrier (Springer)
- Topic blood-brain barrier
A
Microfluidic Multisize Spheroid Array for
Blood-Brain Barrier Screening (Adv
Science, IF 15.44)
The
pivotal role of microenvironmental cells
in stroke blood-brain barrier breakdown
(FBCNS, IF 7.67)
SARS-CoV2
dysregulates the blood-brain barrier and
might enter the CNS (Stem Cell Rep,
IF 7.75)
TAT-MeCP2
as replacement therapy for RETT syndrome
(Int J Biol Macromol, IF 6.95)
- Topic blood-saliva barrier
Development
of salivary gland epithelial cell model
for biomarker studies (Biomedicines, IF
6.08)
CRP
as salivary biomarker for neonatal sepsis
(Pharmaceutics, IF 6.32)
Optimization
of an oral mucosa model (Tissue Barrier)
NEWS:
"Die Krone" article "Medizin
fürs Gehirn" in the newspaper
with the largest readership in
Austria, 26.11.2019 about our work at
AIT.
NEWS: New Future
Science OA Paper about an autologous
4-organ-on-a-chip system
based on human, induced
pluripotent stem cells (hiPSCs).
NEWS: Article
"Am
biochemischen Türsteher vorbeikommen"
in Austrian Newspaper "DiePresse"
about our work.
NEWS: New Nature
Scientific Reports Paper (IF 4.01)
about the development of an ECLIA assay to
measure MeCP2 and application in research
about the Rare Disease RETT syndrome
NEWS: New Annals
of Neurology (IF 10.25) Paper about
the pivotal role of PAI-1 during
fibrinolysis in traumatic brain injury
NEWS: New
ACS Appl
Mater Interfaces (IF 8.09)
Paper about a novel
material to control oxygen levels
at the microscale for e.g. a microfluidic
in vitro stroke model of the blood-brain
barrier
NEWS: New Biomaterials
(IF 8.81) Paper about a novel tool
to transiently open the
blood-brain barrier for drug
delivery of small compounds
NEWS:
New Tissue
Barriers Review about cell
culture models of the blood-saliva
barrier.
NEWS: Article
in Austrian Newspaper "Die
Krone" about our Alternatives to
Animal Testing efforts at EUSAAT (www.eusaat.org)
NEWS:
New Frontier
Molecular Neuroscience Paper (IF
5.08) about the compound
WY-14643 to reduce traumatic brain
injury damage.
NEWS: New Stem
Cell Reports Paper (IF 7.34) about a
novel human blood-brain barrier model based
on human induced, pluripotent stem cells
(hiPSCs).
NEWS:
I am looking forward to my new position at
the Austrian Institute of Technology (AIT,
www.ait.ac.at) starting in April 2016.
NEWS: Link to
the article on the website of the University of
Vienna: "Risiken
und
Nebenwirkungen
in
der
Behandlung Frühgeborener", went online on 9th of
February 2016.
NEWS: New
PlosONE Paper about " Balanced
hydroxyethylstarch
(HES
130/0.4)
impairs
kidney
function
in-vivo without inflammation" went online on 5th
of September 2015.
NEWS: New PlosONE Paper about " Multiple
antenatal
dexamethasone
treatment
alters
brain
vessel
differentation
in
newborn
mouse pups" went online on 14th of August 2015.
NEWS: Winfried
Neuhaus is an Invited
Speaker at the " 2nd Zing Barriers of The CNS Conference"
from 27th to 30th September 2015 in Oropesa, Spain,
and will talk about ischemia in-vitro models, if
interested in the conference follow the link: http://www.zingconferences.com/conferences/2nd-zing-barriers-cns-conference/
NEWS: Link to
the video and article on the website of the University
of Vienna: "Das
Hirn
und sein Hüter"
disclaimer (in German) |
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